Kinopharma

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Exploratory Research

We are performing exploratory research for difficult-to-treat diseases for a better future. We collaborate with the academia, including the Department of Anatomy and Developmental Biology of Kyoto University Graduate School of Medicine.

1.Development of therapeutic drugs for retinopathy
2.Development of cancer related kinase inhibitors
3.Development of drugs that modulate abnormal splicing

Please visit the research section of Kyoto University Department of Anatomical Developmental Biology website for detailed information.

Bibliography

Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton DR, Bates DO, Ladomery MR. (2011) WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.
Cancer Cell. Dec 13;20(6):768-80.

Kuroyanagi, H., Ohno, G., Sakane, H., Maruoka, H., and Hagiwara, M. (2010) . Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans.
Nat Protoc 5, 1495-1517.

Nowak, D.G., Amin, E.M., Rennel, E.S., Hoareau-Aveilla, C., Gammons, M., Damodoran, G., Hagiwara, M., Harper, S.J., Woolard, J., Ladomery, M.R., et al. (2010) Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis.
J Biol Chem 285, 5532-5540.

Takeuchi, A., Hosokawa, M., Nojima, T., and Hagiwara, M. (2010) Splicing reporter mice revealed the evolutionally conserved switching mechanism of tissue-specific alternative exon selection.
PLoS One 5, e10946.
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